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dc.contributor.author Rojo, G
dc.contributor.author Pèlissier, F
dc.contributor.author Sandoval-Rodriguez, A
dc.contributor.author Bacigalupo, A
dc.contributor.author García, V
dc.contributor.author Pinto, R
dc.contributor.author Ortiz, S
dc.contributor.author Botto-Mahan, C
dc.contributor.author Cattan, PE
dc.contributor.author Solari, A
dc.date.accessioned 2024-01-17T15:55:10Z
dc.date.available 2024-01-17T15:55:10Z
dc.date.issued 2020
dc.identifier.uri https://repositorio.uoh.cl/handle/611/734
dc.description.abstract Chagas disease is a public health problem in America. Its parasite, Trypanosoma cruzi, presents different discrete typing units (DTUs), colonizes organs of mammalian hosts in chronic infections, and presents tropism for particular organs in experimental infections. We evaluated T. cruzi tropism towards organs on the naturally infected rodent Octodon degus, identifying the parasites' DTUs, by means of conventional PCR and hybridization. Almost all the analyzed organs presented T. cruzi. More than 42% of the tested oesophagus, skin, skeletal muscle, brain and intestine showed T. cruzi DNA. Other nine types of organs were infected in over 15%. These results suggest that there is some tropism by T. cruzi in chronically infected O. degus. DTU TcV was present in 92.5% of infected organs with identified DTUs; this DTU is frequently reported in human infections in the Southern Cone of South America. Few organs showed mixed DTU infections. This is one of the few reports on the outcome of chronic natural T. cruzi-infection in wild mammal hosts exposed to naturally infected vectors.
dc.description.sponsorship ANID-FONDECYT
dc.description.sponsorship CONICYT-FONDECYT-BECA
dc.description.sponsorship CONICYT-FONDECYT(Comision Nacional de Investigacion Cientifica y Tecnologica (CONICYT)CONICYT FONDECYT)
dc.description.sponsorship ANID-Programa Becas-Doctorado Becas Chile
dc.relation.uri http://dx.doi.org/10.1016/j.exppara.2020.107931
dc.subject Wild host
dc.subject Tissue infection
dc.subject Chagas disease
dc.subject Discrete typing units
dc.title Organs infected with Trypanosoma cruzi and DTU identification in the naturally infected rodent Octodon degus
dc.type Artículo
uoh.revista EXPERIMENTAL PARASITOLOGY
dc.identifier.doi 10.1016/j.exppara.2020.107931
dc.citation.volume 215
dc.identifier.orcid Botto Mahan, Carezza/0000-0002-2726-2188
dc.identifier.orcid Bacigalupo, Antonella/0000-0003-1661-8916
uoh.indizacion Web of Science


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