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dc.contributor.author | Rojo, G | |
dc.contributor.author | Pèlissier, F | |
dc.contributor.author | Sandoval-Rodriguez, A | |
dc.contributor.author | Bacigalupo, A | |
dc.contributor.author | García, V | |
dc.contributor.author | Pinto, R | |
dc.contributor.author | Ortiz, S | |
dc.contributor.author | Botto-Mahan, C | |
dc.contributor.author | Cattan, PE | |
dc.contributor.author | Solari, A | |
dc.date.accessioned | 2024-01-17T15:55:10Z | |
dc.date.available | 2024-01-17T15:55:10Z | |
dc.date.issued | 2020 | |
dc.identifier.uri | https://repositorio.uoh.cl/handle/611/734 | |
dc.description.abstract | Chagas disease is a public health problem in America. Its parasite, Trypanosoma cruzi, presents different discrete typing units (DTUs), colonizes organs of mammalian hosts in chronic infections, and presents tropism for particular organs in experimental infections. We evaluated T. cruzi tropism towards organs on the naturally infected rodent Octodon degus, identifying the parasites' DTUs, by means of conventional PCR and hybridization. Almost all the analyzed organs presented T. cruzi. More than 42% of the tested oesophagus, skin, skeletal muscle, brain and intestine showed T. cruzi DNA. Other nine types of organs were infected in over 15%. These results suggest that there is some tropism by T. cruzi in chronically infected O. degus. DTU TcV was present in 92.5% of infected organs with identified DTUs; this DTU is frequently reported in human infections in the Southern Cone of South America. Few organs showed mixed DTU infections. This is one of the few reports on the outcome of chronic natural T. cruzi-infection in wild mammal hosts exposed to naturally infected vectors. | |
dc.description.sponsorship | ANID-FONDECYT | |
dc.description.sponsorship | CONICYT-FONDECYT-BECA | |
dc.description.sponsorship | CONICYT-FONDECYT(Comision Nacional de Investigacion Cientifica y Tecnologica (CONICYT)CONICYT FONDECYT) | |
dc.description.sponsorship | ANID-Programa Becas-Doctorado Becas Chile | |
dc.relation.uri | http://dx.doi.org/10.1016/j.exppara.2020.107931 | |
dc.subject | Wild host | |
dc.subject | Tissue infection | |
dc.subject | Chagas disease | |
dc.subject | Discrete typing units | |
dc.title | Organs infected with Trypanosoma cruzi and DTU identification in the naturally infected rodent Octodon degus | |
dc.type | Artículo | |
uoh.revista | EXPERIMENTAL PARASITOLOGY | |
dc.identifier.doi | 10.1016/j.exppara.2020.107931 | |
dc.citation.volume | 215 | |
dc.identifier.orcid | Botto Mahan, Carezza/0000-0002-2726-2188 | |
dc.identifier.orcid | Bacigalupo, Antonella/0000-0003-1661-8916 | |
uoh.indizacion | Web of Science |
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