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dc.contributor.author Villaseca, P
dc.contributor.author Cisternas, P
dc.contributor.author Inestrosa, NC
dc.date.accessioned 2024-01-17T15:54:55Z
dc.date.available 2024-01-17T15:54:55Z
dc.date.issued 2022
dc.identifier.uri https://repositorio.uoh.cl/handle/611/662
dc.description.abstract Late onset Alzheimer's disease (AD) is a neurodegenerative disease with gender differences in its onset and progression, being the prevalence predominant in women and at an earlier age than in men. The pathophysiology of the menopausal condition has been associated to this dementia, playing major roles regarding both endocrine and glucose metabolism changes, amongst other mechanisms. In the current review we address the role of estrogen deficiency in the processes involved in the development of AD, including amyloid precursor protein (APP) processing to form senile plaques, Tau phosphorylation forming neurofibrillary tangles, Wnt signaling and AD neuropathology, the role of glucose brain metabolism, Wnt signaling and glucose transport in the brain, and our research contribution to these topics.
dc.description.sponsorship Basal Centre of Excellence in Aging and Regeneration from ANID (Agencia Nacional de Investigacion y Desarrollo of Chile)
dc.relation.uri http://dx.doi.org/10.3389/fendo.2022.1021796
dc.subject wnt signaling
dc.subject menopause
dc.subject estrogen
dc.subject glucose brain metabolism
dc.subject alzheimer's disease
dc.subject tau phosphorylation
dc.subject APP- amyloid precursor protein
dc.title Menopause and development of Alzheimer's disease: Roles of neural glucose metabolism and Wnt signaling
dc.type Artículo
uoh.revista FRONTIERS IN ENDOCRINOLOGY
dc.identifier.doi 10.3389/fendo.2022.1021796
dc.citation.volume 13
dc.identifier.orcid CISTERNAS, PEDRO/0000-0001-7796-8982
uoh.indizacion Web of Science


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