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dc.contributor.author Valladares-Ide, D
dc.contributor.author Bravo, MJ
dc.contributor.author Carvajal, A
dc.contributor.author Araneda, OF
dc.contributor.author Tuesta, M
dc.contributor.author Reyes, A
dc.contributor.author Peñailillo, R
dc.contributor.author Peñailillo, L
dc.date.accessioned 2024-01-17T15:54:08Z
dc.date.available 2024-01-17T15:54:08Z
dc.date.issued 2021
dc.identifier.uri https://repositorio.uoh.cl/handle/611/368
dc.description.abstract Purpose The purpose of this study was to compare pulmonary and plasma markers of oxidative stress and inflammation after concentric and eccentric cycling bouts in individuals with chronic obstructive pulmonary disease (COPD). Methods Ten patients with moderate COPD level (68.3 +/- 9.1 years; forced expiratory volume in 1 s = 68.6 +/- 20.4% of predicted) performed 30 min of moderate-intensity concentric (CONC-M: 50% maximum concentric cycling power output; POmax) and eccentric cycling (ECC-M: 50% POmax), and high-intensity eccentric cycling (ECC-H: 100% POmax) in a randomised order. Cardiometabolic demand was monitored during cycling. Indirect markers of muscle damage were assessed before, immediately after, 24 and 48 h after cycling (muscle strength, muscle soreness and creatine kinase activity). Plasma oxidative stress (malondialdehyde: MDA), antioxidant (glutathione peroxidase activity: GPx) and inflammatory markers (IL-6, TNF-alpha) were measured before and 5 min after cycling. Exhaled breath condensate (EBC) samples were collected before and 15 min after cycling and analysed for hydrogen peroxide (H2O2), nitrites (NO2-) and pH. Results Cardiometabolic demand was 40-50% lesser for ECC-M than CONC-M and ECC-H. Greater muscle damage was induced after ECC-H than ECC-M and CONC-M. MDA decreased immediately after CONC-M (- 28%), ECC-M (- 14%), and ECC-H (- 17%), while GPx remained unchanged. IL-6 increased only after ECC-H (28%), while TNF-alpha remained unchanged after exercise. Pulmonary H2O2, NO2- and pH remained unchanged after exercise. Conclusion These results suggest that only moderate muscle damage and inflammation were induced after high-intensity eccentric cycling, which did not induce pulmonary or plasmatic increases in markers of oxidative stress.
dc.description.sponsorship CONICYT of Chile(Comision Nacional de Investigacion Cientifica y Tecnologica (CONICYT))
dc.relation.uri http://dx.doi.org/10.1007/s00421-021-04652-1
dc.subject Lengthening
dc.subject COPD
dc.subject TNF-α TBARS
dc.subject Exhaled breath condensate
dc.subject Interleukin-6
dc.title Changes in pulmonary and plasma oxidative stress and inflammation following eccentric and concentric cycling in stable COPD patients
dc.type Artículo
uoh.revista EUROPEAN JOURNAL OF APPLIED PHYSIOLOGY
dc.identifier.doi 10.1007/s00421-021-04652-1
dc.citation.volume 121
dc.citation.issue 6
dc.identifier.orcid Peñailillo, Luis E/0000-0001-7697-9700
dc.identifier.orcid Reyes, Alvaro/0000-0001-7703-2893
dc.identifier.orcid Valladares-Ide, Denisse/0000-0001-7625-7978
dc.identifier.orcid Penailillo, Reyna/0000-0001-5300-1208
uoh.indizacion Web of Science


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