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dc.contributor.author Figueroa, EG
dc.contributor.author Gonzaléz-Candia, A
dc.contributor.author Villanueva, CA
dc.contributor.author Ebensperger, G
dc.contributor.author Reyes, RV
dc.contributor.author Llanos, AJ
dc.contributor.author Herrera, EA
dc.date.accessioned 2024-01-17T15:54:04Z
dc.date.available 2024-01-17T15:54:04Z
dc.date.issued 2021
dc.identifier.uri https://repositorio.uoh.cl/handle/611/348
dc.description.abstract Pulmonary arterial hypertension of the newborn (PAHN) is a syndrome caused by chronic hypoxia, characterized by decreased vasodilator function, a marked vasoconstrictor activity, proliferation of smooth muscle cells (SMC) and thickening of the extracellular matrix in the pulmonary circulation, among other characteristics. Prostaglandins are derived from the arachidonic acid (AA) metabolism and are important regulators of pulmonary vascular tone. Since hypoxia induces oxidative stress and has been related to PAHN, a postnatal treatment with melatonin has been proposed due to its antioxidant properties. Here, we determined the effects of melatonin on pulmonary vascular homeostasis given by prostanoids. Ten PAHN newborn lambs were divided in two groups and treated either with vehicle or melatonin. After 1 week of treatment, we assessed pulmonary vascular prostanoids function and expression by wire myography, RT-PCR, Western Blot and immunohistochemistry. Melatonin improved in vivo and ex vivo pulmonary vasodilation. This was associated with an increased function and expression of vasodilator prostanoids at the expense of vasoconstrictor prostanoids. Our study demonstrates for the first time that melatonin may enhance the vasodilator prostanoid pathway in PAHN.
dc.description.sponsorship FONDECYT(Comision Nacional de Investigacion Cientifica y Tecnologica (CONICYT)CONICYT FONDECYT)
dc.description.sponsorship Proyectos Puente ICBM, Facultad de Medicina, Universidad de Chile
dc.relation.uri http://dx.doi.org/10.1016/j.vph.2021.106853
dc.subject Prostanoids
dc.subject Chronic hypoxia
dc.subject Vascular reactivity
dc.subject Vascular remodeling
dc.subject Prostacyclin
dc.subject Thromboxane
dc.subject Lambs
dc.title Beneficial effects of melatonin on prostanoids pathways in pulmonary hypertensive neonates
dc.type Artículo
uoh.revista VASCULAR PHARMACOLOGY
dc.identifier.doi 10.1016/j.vph.2021.106853
dc.citation.volume 138
dc.identifier.orcid Gonzalez-Candia, Alejandro/0000-0001-8429-367X
dc.identifier.orcid Figueroa, Esteban/0000-0003-1316-738X
dc.identifier.orcid Herrera, Emilio A/0000-0002-6342-085X
uoh.indizacion Web of Science


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