https://repositorio.uoh.cl/handle/611/20 2026-04-25T20:58:06Z https://repositorio.uoh.cl/handle/611/858 Stigma Toward Psychosis in Urban Chile: Engaging What Matters Most to Resist Stigma Through Recovery-Oriented Services Becker, TD; Blasco, D; Burrone, MS; Dishy, G; Velasco, P; Reginatto, G; Mascayano, F; Wu, MS; Hu, C; Bharadwaj, S; Khattar, S; Calderon, L; Filgueira, C; Alvarado, R; Susser, ES; Yang, LH Objective: Stigma jeopardizes recovery and successful implementation of mental health services (MHS) globally. Despite cultural variation in how stigma manifests, few studies have examined how culture fundamentally impacts the concept of personhood in Latin America. Chile has expanded MHS, providing universal coverage for evaluation and treatment of first episode psychosis (FEP). We applied the what matters most (WMM) framework of stigma to identify culturally salient factors that shape or protect against stigma in urban Chile, identifying potential implications for MHS and recovery. Methods: In-depth interviews (n = 48) were conducted with MHS users with psychotic disorders (n = 18), their family members (n = 15), and community members (n = 15), from two urban regions in Chile. Interviews were coded and analyzed to identify WMM, how WMM shapes stigma, and how MHS can influence achieving WMM. Results: Traditional values emphasizing physical/social appearance, gender roles, family, and social connectedness are highly valued. Socioeconomic transitions have engendered capitalistic variations on traditional values, with increasing emphasis on professional careers for men and women, individualism, and independence. Psychotic disorders interfere with fulfillment of both traditional and capitalist values, thereby reinforcing stigma. However, MHS are seen as partially effective in enabling fulfillment of some goals, including employment, appearance, and independence, while often remaining insufficient in enabling capacity to achieve marriage and having a family. Conclusions and Implications for Practice: MHS that facilitate recovery by engaging users in services, such as pharmacotherapy, education/vocational rehabilitation, and family-centered care aligned with cultural values can mitigate stigma and facilitate recovery by enabling users to fulfill WMM. 2023-01-01T00:00:00Z https://repositorio.uoh.cl/handle/611/439 Difference in Perseverative Errors during a Visual Attention Task with Auditory Distractors in Alpha-9 Nicotinic Receptor Subunit Wild Type and Knock-Out Mice Jorratt, P; Delano, PH; Delgado, C; Dagnino-Subiabre, A; Terreros, G The auditory efferent system is a neural network that originates in the auditory cortex and projects to the cochlear receptor through olivocochlear (OC) neurons. Medial OC neurons make cholinergic synapses with outer hair cells (OHCs) through nicotinic receptors constituted by alpha 9 and alpha 10 subunits. One of the physiological functions of the alpha 9 nicotinic receptor subunit (alpha 9-nAChR) is the suppression of auditory distractors during selective attention to visual stimuli. In a recent study we demonstrated that the behavioral performance of alpha-9 nicotinic receptor knock-out (KO) mice is altered during selective attention to visual stimuli with auditory distractors since they made less correct responses and more omissions than wild type (WT) mice. As the inhibition of the behavioral responses to irrelevant stimuli is an important mechanism of the selective attention processes, behavioral errors are relevant measures that can reflect altered inhibitory control. Errors produced during a cued attention task can be classified as premature, target and perseverative errors. Perseverative responses can be considered as an inability to inhibit the repetition of an action already planned, while premature responses can be considered as an index of the ability to wait or retain an action. Here, we studied premature, target and perseverative errors during a visual attention task with auditory distractors in WT and KO mice. We found that alpha 9-KO mice make fewer perseverative errors with longer latencies than WT mice in the presence of auditory distractors. In addition, although we found no significant difference in the number of target error between genotypes, KO mice made more short-latency target errors than WT mice during the presentation of auditory distractors. The fewer perseverative error made by alpha 9-KO mice could be explained by a reduced motivation for reward and an increased impulsivity during decision making with auditory distraction in KO mice. 2017-01-01T00:00:00Z https://repositorio.uoh.cl/handle/611/254 On track program for first episode psychosis services in chile: stakeholders perspective in the adaptation phase Burrone, M.S; Reginatto, G; Arriata, T; Velasco, P; Susser, E; Dixon, L; Alvarado, R; Yang, L; Bello, I; Cabassa, L 2020-01-01T00:00:00Z https://repositorio.uoh.cl/handle/611/251 OnTrack Chile for people with early psychosis: a study protocol for a Hybrid Type 1 trial Mascayano, Franco; Bello, Iruma; Andrews, Howard; Arancibia, Diego; Arratia, Tamara; Burrone, María; Conover, Sarah; Fader, Kim; Jorquera, Maria Jose; Gomez, Mauricio; Malverde, Sergio; Martínez‑Alés, Gonzalo; Ramírez, Jorge; Reginatto, Gabriel; Restrepo‑Henao, Alexandra; Rosencheck, Robert A; Schilling, Sara; Smith, Thomas E; Soto‑Brandt, Gonzalo; Tapia, Eric; Tapia, Tamara; Velasco, Paola; Wall, Melanie M; Yang, Lawrence H; Cabassa, Leopoldo J.; Susser, Ezra; Dixon, Lisa; Alvarado, Rubén Substantial data from high-income countries support early interventions in the form of evidencebased Coordinated Specialty Care (CSC) for people experiencing First episode Psychosis (FEP) to ameliorate symptoms and minimize disability. Chile is unique among Latin American countries in providing universal access to FEP services through a national FEP policy that mandates the identifcation of FEP individuals in primary care and guarantees delivery of community-based FEP treatments within a public health care system. Nonetheless, previous research has documented that FEP services currently provided at mental health clinics do not provide evidence-based approaches. This proposal aims to address this shortfall by frist adapting OnTrackNY (OTNY), a CSC program currently being imple‑mented across the USA, into OnTrackChile (OTCH), and then examine its efectiveness and implementation in Chile. 2020-01-01T00:00:00Z